Li L, Liang H Q, Liao S X, Qiao C Z, Yang G J, Dong T Y
School of Pharmacy, Second Military Medical University, Shanghai.
Yao Xue Xue Bao. 1993;28(3):238-40.
Seven compounds have been isolated from the whole plant of Strobilanthes cusia (Nees) O. Ktze. Three of them are triterpenes (I-III), two are indole alkaloids (IV, V), two are quinazolinone alkaloids (VI, VII). On the basis of spectral analysis and physicochemical properties, their structures were established as lupeol (I), betulin (II), lupenone (III), indigo (IV), indirubin (V), 4(3H)-quinazolinone (VI), 2,4(1H,3H)-quinazolinedione (VII). VI and VII were found from natural plant for the first time. The results of the pharmacological tests demonstrate that compound V has anticancer activity and compound VI has hypotensive action. Compound VII can be quantitatively determined by HPLC, which may serve as a quality control standard for materia medica and its preparations. Compounds VI and VII have been confirmed by means of synthesis.
从马蓝（Strobilanthes cusia (Nees) O. Ktze.）全草中分离得到了七种化合物。其中三种为三萜类化合物（I - III），两种为吲哚生物碱（IV，V），两种为喹唑啉酮生物碱（VI，VII）。基于光谱分析和理化性质，确定它们的结构分别为羽扇豆醇（I）、白桦脂醇（II）、羽扇豆酮（III）、靛蓝（IV）、靛玉红（V）、4(3H)-喹唑啉酮（VI）、2,4(1H,3H)-喹唑啉二酮（VII）。VI和VII首次从天然植物中发现。药理试验结果表明，化合物V具有抗癌活性，化合物VI具有降压作用。化合物VII可用高效液相色谱法定量测定，可作为药材及其制剂的质量控制标准。化合物VI和VII已通过合成得到确证。
