Department of Pharmacology, M. M. College of Pharmacy, M. M. University, Mullana, Ambala, 133203, Haryana, India.
Inflammopharmacology. 2013 Jun;21(3):233-9. doi: 10.1007/s10787-012-0150-8. Epub 2012 Sep 17.
To assess the protective efficacy of Strobilanthes callosus against the acute and chronic inflammation on rat model.
Inflammation was induced by carrageen and Freund's complete adjuvant in plantar surface of the rats. The ethanol, chloroform and petroleum ether extracts in three divided doses (100, 200 and 400 mg/kg) were administered orally. Diclofenac sodium (10 mg/kg), prednisolone (5 mg/kg) and methotrexate (0.5 mg/kg) were used as standard. The statistical significance between means was analyzed using a one-way analysis of variance followed by Tukey's multiple comparison test. A p <0.005 was considered as statistically significant.
Pet. ether (200 and 400 mg/kg) and ethanol extract (100 and 400 mg/kg) showed statistically significant (p < 0.001) effect in analgesic activity. In a carrageen-induced model, only pet. ether extract (100 and 400 mg/kg) confirmed statistically significant effect (p < 0.001) at every interval (four in all) of 1 h. In Freund's adjuvant model, Pet ether and ethanol extract (200 and 400 mg/kg) have shown statistically significant effect (p < 0.001) and in case of chloroform extract only single dose (400 mg/kg) were observed statistically significant results considered to be anti-arthritic effects. The histopathology pictures showed there was positive inhibition of arthritis at a certain level in different groups compared to positive control group.
Pet. ether and ethanol extracts of S. callosus were observed to have a promising efficacy against acute and chronic inflammation.
评估肾茶对大鼠急、慢性炎症模型的保护作用。
采用角叉菜胶和弗氏完全佐剂诱导大鼠足底炎症。以双氯芬酸钠（10mg/kg）、泼尼松龙（5mg/kg）和甲氨蝶呤（0.5mg/kg）为阳性对照药，分别灌胃给予肾茶的乙醇、氯仿和石油醚提取物（100、200 和 400mg/kg）3 个剂量。采用单因素方差分析和 Tukey 多重比较检验进行统计学分析。p＜0.05 表示差异有统计学意义。
石油醚提取物（200 和 400mg/kg）和乙醇提取物（100 和 400mg/kg）在镇痛活性方面表现出显著的统计学意义（p＜0.001）。在角叉菜胶诱导的模型中，只有石油醚提取物（100 和 400mg/kg）在所有 4 个时间点（每 1 小时 1 次）均表现出显著的统计学效果（p＜0.001）。在弗氏佐剂模型中，石油醚和乙醇提取物（200 和 400mg/kg）表现出显著的统计学效果（p＜0.001），而氯仿提取物仅在单剂量（400mg/kg）时观察到统计学显著结果，被认为具有抗关节炎作用。组织病理学图片显示，与阳性对照组相比，不同组在不同程度上对关节炎有积极的抑制作用。
肾茶的石油醚和乙醇提取物对急、慢性炎症具有潜在的疗效。
