一种使用光电二极管阵列检测器的法医毒理学中不依赖类别药物筛查。
A class-independent drug screen in forensic toxicology using a photodiode array detector.
作者信息
Drummer O H, Kotsos A, McIntyre I M
机构信息
Victorian Institute of Forensic Pathology, Monash University, South Melbourne, Australia.
出版信息
J Anal Toxicol. 1993 Jul-Aug;17(4):225-9. doi: 10.1093/jat/17.4.225.
A class-independent drug screen, that is suitable for use in clinical and forensic toxicology and uses gradient-elution high-performance liquid chromatography and photodiode array detection, is presented. The assay is capable of detecting and identifying therapeutic and toxic amounts of barbiturates, anti-convulsants, diuretics, non-steroidal anti-inflammatory drugs, sulfonylurea anti-diabetic drugs, theophylline, and analgesic drugs. The assay has been successfully used to screen over 1000 postmortem blood specimens.
本文介绍了一种与类别无关的药物筛查方法，该方法适用于临床和法医毒理学，采用梯度洗脱高效液相色谱法和光电二极管阵列检测法。该检测方法能够检测和识别治疗剂量及中毒剂量的巴比妥类药物、抗惊厥药、利尿剂、非甾体抗炎药、磺脲类抗糖尿病药、茶碱和镇痛药。该检测方法已成功用于筛查1000多份尸检血液标本。
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