Spratt E, Vallaro G M
Westchester County Department of Laboratories and Research, Valhalla, New York, USA.
Clin Lab Med. 1998 Dec;18(4):651-63, viii.
Many instruments are used in forensic toxicology to screen biologic samples for drugs and other compounds. Many of these screening instruments (and others) are used to confirm positive screening tests. The focus of this article is the use of a high pressure liquid chromatograph/mass spectrometer (HPLC/MS) for screening forensic postmortem and human performance DWI cases. This screening procedure involves an HPLC with a particle beam interfaced to a mass spectrometer detector and a photodiode array detector. Drugs such as the antidepressants, drugs of abuse, over-the-counter cold and pain preparations, anticonvulsants, benzodiazepines, and some medications that are not available in the United States are selected at therapeutic and subtherapeutic levels. Limits of detection and extraction efficiencies are presented for many compounds. Several cases are discussed showing different drug combinations.
法医毒理学中使用了许多仪器来筛查生物样本中的药物和其他化合物。其中许多筛查仪器（以及其他仪器）用于确证阳性筛查结果。本文的重点是使用高压液相色谱仪/质谱仪（HPLC/MS）筛查法医尸检和人体酒驾案件。该筛查程序涉及一台与质谱仪检测器和光电二极管阵列检测器相连的带粒子束的高效液相色谱仪。选择了如抗抑郁药、滥用药物、非处方感冒和止痛制剂、抗惊厥药、苯二氮卓类药物以及一些在美国无法获得的药物，并设定了治疗和亚治疗水平。给出了许多化合物的检测限和提取效率。讨论了几起显示不同药物组合的案例。
