Durieux M E, Lynch K R
University of Virginia, Charlottesville 22908.
Trends Pharmacol Sci. 1993 Jun;14(6):249-54. doi: 10.1016/0165-6147(93)90021-b.
Lysophosphatidic acid (LPA) is the simplest natural phospholipid, primarily known as a membrane component and metabolic intermediate. However, a remarkable variety of biological effects of this compound have come to light, seemingly pointing to an additional role for LPA as a signalling molecule. In this review, Marcel Durieux and Kevin Lynch integrate the recent information that indicates that LPA could be an intercellular messenger, possibly acting through a G protein-coupled receptor, and with a role in cell growth and motility.
溶血磷脂酸（LPA）是最简单的天然磷脂，主要作为膜成分和代谢中间体为人所知。然而，这种化合物具有多种多样显著的生物学效应，这似乎表明LPA还具有信号分子的作用。在这篇综述中，马塞尔·迪里厄和凯文·林奇整合了近期的信息，这些信息表明LPA可能是一种细胞间信使，可能通过G蛋白偶联受体发挥作用，并在细胞生长和运动中起作用。
