Amatruda J M, Statt M C, Welle S L
Department of Medicine, University of Rochester School of Medicine, New York.
J Clin Invest. 1993 Sep;92(3):1236-42. doi: 10.1172/JCI116695.
Obesity could be due to excess energy intake or decreased energy expenditure (EE). To evaluate this, we studied 18 obese females (148 +/- 8% of ideal body weight [IBW], mean +/- SD) before and after achieving and stabilizing at IBW for at least 2 mo and a control group of 14 never obese females (< 110% of IBW or < 30% fat). In the obese, reduced obese, and never obese groups, the percent of body fat was 41 +/- 4%, 27 +/- 4%, and 25 +/- 3%; total energy expenditure (TEE) was 2704 +/- 449, 2473 +/- 495, and 2259 +/- 192 kcal/24 h; while resting metabolic rate was 1496 +/- 169, 1317 +/- 159, and 1341 +/- 103 kcal/24 h, respectively. 15 obese subjects who withdrew from the study had a mean initial body composition and EE similar to the subjects who were successful in achieving IBW. In 10 subjects followed for at least one year after stabilizing at IBW there was no significant relationship between the deviation from predicted TEE at IBW and weight regain. These studies indicate that, in a genetically heterogeneous female population, neither the propensity to become obese nor to maintain the obese state are due to an inherent metabolic abnormality characterized by a low EE.
肥胖可能是由于能量摄入过多或能量消耗（EE）减少所致。为了对此进行评估，我们研究了18名肥胖女性（体重为理想体重[IBW]的148±8%，均值±标准差），她们在达到并稳定在IBW至少2个月前后的情况，以及一个由14名从未肥胖的女性组成的对照组（体重<IBW的110%或体脂<30%）。在肥胖组、减重后肥胖组和从未肥胖组中，体脂百分比分别为41±4%、27±4%和25±3%；总能量消耗（TEE）分别为2704±449、2473±495和2259±192千卡/24小时；静息代谢率分别为1496±169、1317±159和1341±103千卡/24小时。退出研究的15名肥胖受试者的初始身体成分和EE均值与成功达到IBW的受试者相似。在10名在稳定在IBW后随访至少一年的受试者中，与IBW时预测的TEE的偏差与体重反弹之间没有显著关系。这些研究表明，在遗传异质性的女性群体中，无论是肥胖倾向还是维持肥胖状态都不是由于以低EE为特征的内在代谢异常所致。
