Tinwell H, Yendle J, Ashby J
Zeneca Central Toxicology Laboratory, Alderley Park, Cheshire, UK.
Mutat Res. 1996 Oct 1;370(3-4):141-3. doi: 10.1016/s0165-1218(96)00047-x.
N-Propyl-N-nitrosourea (PNU) is shown to be active in male mouse bone marrow micronucleus assays when dosed at either 100 or 200 mg/kg in saline. Activity was observed following either intraperitoneal (i.p.) injection or oral gavage. This observation is consistent with the demonstration by Murota and Shibuya of the specific-locus mutagenicity caused by PNU in male mouse spermatogonia when dosed at 200 mg/kg by i.p. injection. These data strengthen further the observation that rodent germ cell mutagens are also mutagenic to rodent somatic cells.
