Bertilsson L, Haglund K, Ostman J, Rawlins M D, Ringberger V A, Sjöqvist F
Eur J Clin Pharmacol. 1977 Jan 3;11(2):125-8. doi: 10.1007/BF00562903.
Lumbar cerebrospinal fluid (CSF) concentrations of the major metabolites of noradrenaline (4-hydroxy-3-methoxyphenyl glycol, HMPG), serotonin (5-hydroxyindoleacetic acid) and dopamine (homovanillic acid) were measured before and during the administration of clonidine or alprenolol to hypertensive patients. The noradrenaline receptor stimulant clonidine significantly decreased the CSF level of HMPG, but there was no consistent change in the concentration of serotonin or dopamine metabolites. Patients on alprenolol showed no change in the levels of these metabolites in CSF.
在对高血压患者给予可乐定或阿普洛尔之前及期间，测量其脑脊液（CSF）中去甲肾上腺素的主要代谢产物（4-羟基-3-甲氧基苯乙二醇，HMPG）、5-羟色胺（5-羟吲哚乙酸）和多巴胺（高香草酸）的浓度。去甲肾上腺素受体激动剂可乐定显著降低了HMPG的脑脊液水平，但5-羟色胺或多巴胺代谢产物的浓度没有一致的变化。服用阿普洛尔的患者脑脊液中这些代谢产物的水平没有变化。
