Lyte M, Ernst S
Department of Biological Sciences, Mankato State University, MN 56002.
Biochem Biophys Res Commun. 1993 Jan 29;190(2):447-52. doi: 10.1006/bbrc.1993.1068.
The effect of a number of adrenergic receptor agonists and antagonists on the growth of Escherichia coli and Yersinia enterocolitica was examined in order to delineate possible receptor mechanism(s) by which the catecholamines influence the growth of gram-negative bacteria. Neither alpha or beta adrenergic receptor agonists or antagonists affected growth in a dose-dependent manner similar to that observed for norepinephrine. The physiological less active enantiomer of norepinephrine, (+)-norepinephrine, did not affect catecholamine-induced growth to a similar degree as that observed with the active enantiomer. These results suggest that a non-alpha, non-beta adrenergic receptor mediated process may play a role in catecholamine-induced growth of gram-negative bacteria.
为了阐明儿茶酚胺影响革兰氏阴性菌生长的可能受体机制，研究了多种肾上腺素能受体激动剂和拮抗剂对大肠杆菌和小肠结肠炎耶尔森菌生长的影响。无论是α还是β肾上腺素能受体激动剂或拮抗剂，均未以类似于去甲肾上腺素的剂量依赖性方式影响生长。去甲肾上腺素生理活性较低的对映体（+）-去甲肾上腺素，对儿茶酚胺诱导的生长的影响程度与活性对映体观察到的不同。这些结果表明，非α、非β肾上腺素能受体介导的过程可能在儿茶酚胺诱导的革兰氏阴性菌生长中起作用。
