Mikos A G, Bao Y, Cima L G, Ingber D E, Vacanti J P, Langer R
Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge 02139.
J Biomed Mater Res. 1993 Feb;27(2):183-9. doi: 10.1002/jbm.820270207.
A novel method was developed to prepare three-dimensional structures with desired shapes used as templates for cell transplantation. The produced biomaterials are highly porous with large surface/volume and provide the necessary space for attachment and proliferation of the transplanted cells. The processing technique calls for the formation of a composite material with nonbonded fibers embedded in a matrix followed by thermal treatment and the selective dissolution of the matrix. To evaluate the technique, poly(glycolic acid) (PGA) fiber meshes were bonded using poly(L-lactic acid) (PLLA) as a matrix. The bonded structures were highly porous with values of porosity up to 0.81 and area/volume ratios as high as 0.05 micron-1.
开发了一种新方法来制备具有所需形状的三维结构，用作细胞移植的模板。所制备的生物材料具有高度多孔性，表面积/体积大，为移植细胞的附着和增殖提供了必要空间。该加工技术要求形成一种复合材料，其中非粘结纤维嵌入基质中，然后进行热处理并选择性溶解基质。为了评估该技术，使用聚（L-乳酸）（PLLA）作为基质粘结聚乙醇酸（PGA）纤维网。粘结结构具有高度多孔性，孔隙率高达0.81，面积/体积比高达0.05微米-1。
