Filgueiras M R, La Torre G, Hench L L
College of Engineering, University of Florida, Alachua 32615.
J Biomed Mater Res. 1993 Apr;27(4):445-53. doi: 10.1002/jbm.820270405.
The in vitro surface reactions of a 45S5 bioactive glass in three simulated body fluids (SBF) are analyzed using Fourier transform infrared (FTIR) spectroscopy. Five reaction stages are observed. Calcium and phosphate ions in SBF accelerate to a small extent the repolymerization of silica (Stage 3) and formation of an amorphous calcium-phosphate (a-CP) layer (Stage 4) on the glass surface. The a-CaP layer is crystallized to form hydroxy-carbonate apatite (HCAp) (Stage 5) more rapidly in the Ca- and P-containing SBF solutions (in 90 min rather than 120 min). However, Mg ions in SBF slow down formation of the a-CaP layer and greatly retard crystallization of HCAp on the glass surface.
使用傅里叶变换红外光谱（FTIR）分析了45S5生物活性玻璃在三种模拟体液（SBF）中的体外表面反应。观察到五个反应阶段。SBF中的钙和磷酸根离子在一定程度上加速了二氧化硅的再聚合（阶段3）以及玻璃表面无定形磷酸钙（a-CP）层的形成（阶段4）。在含Ca和P的SBF溶液中，a-CaP层更快地结晶形成羟基碳酸磷灰石（HCAp）（阶段5）（90分钟而不是120分钟）。然而，SBF中的Mg离子减缓了a-CaP层的形成，并极大地阻碍了玻璃表面HCAp的结晶。
