Connecticut Convergence Institute for Translation in Regenerative Engineering, University of Connecticut Health, Farmington, CT, USA.
Raymond and Beverly Sackler Center for Biological, Physical and Engineering Sciences, University of Connecticut Health, Farmington, CT, USA.
J Dent Res. 2021 Sep;100(10):1011-1019. doi: 10.1177/00220345211010436. Epub 2021 Apr 27.
Regenerative engineering has pioneered several novel biomaterials to treat critical-sized bone injuries. However, despite significant improvement in synthetic materials research, some limitations still exist. The constraints correlated with the current grafting methods signify a treatment paradigm shift to osteoinductive regenerative engineering approaches. Because of their intrinsic potential, inductive biomaterials may represent alternative approaches to treating critical bone injuries. Osteoinductive scaffolds stimulate stem cell differentiation into the osteoblastic lineage, enhancing bone regeneration. Inductive biomaterials comprise polymers, calcium phosphate ceramics, metals, and graphene family materials. This review will assess the cellular behavior toward properties of inductive materials.
再生工程开创了几种新型生物材料来治疗临界尺寸的骨损伤。然而，尽管在合成材料研究方面取得了重大进展，但仍存在一些局限性。与当前移植方法相关的限制表明需要向诱导性再生工程方法转变。由于其内在的潜力，诱导性生物材料可能代表了治疗临界骨损伤的另一种方法。诱导性支架刺激干细胞向成骨细胞系分化，从而增强骨再生。诱导性生物材料包括聚合物、磷酸钙陶瓷、金属和石墨烯家族材料。本文将评估细胞对诱导材料性能的反应。
