Bernstein L, Deapen D, Ross R K
Department of Preventive Medicine, University of Southern California School of Medicine, Los Angeles 90033.
Cancer. 1993 May 15;71(10):3020-4. doi: 10.1002/1097-0142(19930515)71:10<3020::aid-cncr2820711022>3.0.co;2-g.
Malignant cystosarcoma phyllodes tumors of the breast are rare fibroepithelial tumors. The epidemiologic features of these malignancies in a defined population have not previously been described.
Incidence data were collected from 1972-1989 by the Cancer Surveillance Program, the population-based cancer registry for Los Angeles County.
The average annual age-adjusted incidence rate of malignant cystosarcoma phyllodes is 2.1 per 1 million women. Latina whites have a higher risk of this cancer than other racial-ethnic groups. The age-incidence curve shows that risk of cystosarcoma phyllodes peaks in the 45-49-year-old age group, but the age patterns vary by race-ethnicity, with Asian and Latina patients significantly younger, on average, than non-Latina white patients. The incidence rates of malignant cystosarcoma phyllodes were substantially higher in the 1980s than in the 1970s, particularly among Latina whites and Asians. For Latina whites, birthplace is a significant predictor of risk. Women born in Mexico and Central and South America are at threefold to fourfold greater risk of malignant cystosarcoma phyllodes tumors than Latina whites born in the United States.
The epidemiology of malignant cystosarcoma phyllodes tumors of the breast is strikingly different from that of the more common histologic types of breast cancer. The high risk in Latina immigrants may offer an important clue as to the cause of this rare tumor.
乳腺恶性叶状囊肉瘤是一种罕见的纤维上皮性肿瘤。此前尚未描述过这些恶性肿瘤在特定人群中的流行病学特征。
通过癌症监测项目收集了1972年至1989年的数据，该项目是洛杉矶县基于人群的癌症登记处。
乳腺恶性叶状囊肉瘤的年龄调整后年均发病率为每100万女性2.1例。拉丁裔白人患这种癌症的风险高于其他种族/族裔群体。年龄发病率曲线显示，叶状囊肉瘤的风险在45至49岁年龄组达到峰值，但年龄模式因种族/族裔而异，亚洲和拉丁裔患者平均比非拉丁裔白人患者年轻得多。20世纪80年代乳腺恶性叶状囊肉瘤的发病率显著高于70年代，尤其是在拉丁裔白人和亚洲人中。对于拉丁裔白人来说，出生地是风险的一个重要预测因素。出生在墨西哥以及中美洲和南美洲的女性患乳腺恶性叶状囊肉瘤的风险是非美国出生的拉丁裔白人的三到四倍。
乳腺恶性叶状囊肉瘤的流行病学与更常见的乳腺癌组织学类型显著不同。拉丁裔移民的高风险可能为这种罕见肿瘤的病因提供重要线索。
