Jang Chul Ho, Park Haekyun, Cho Yong Bum, Choi Cheol Hee, Song Changhun
Department of Otolaryngology, Chonnam National University Medical School, Gwangju, South Korea.
In Vivo. 2009 Jan-Feb;23(1):183-5.
There has been a steady increase in the number of cases of ciprofloxacin-resistant Pseudomonas aeruginosa (CRPA) otorrhea; this is a growing medical concern. For otological surgery in children, octylcyanoacrylate can be an alternative method of closure for surgical incisions. Recent in vitro studies have shown that octylcyanoacrylate is effective as an antimicrobical barrier. To date, there have been only rare reports on the antibacterial effect of octylcyanoacrylate against CRPA. The purpose of this study is to determine the antimicrobial effects of octyl-cyanoacrylate against the CRPA that was isolated from patients with chronic suppurative otitis media.
Clinical CRPA (n=20) bacteria and ciprofloxacin-sensitive PA (CSPA) (n=20) were obtained from patients. The susceptibilities to various antibiotics were determined by disk diffusion method.
Both CSPA and CRPA were resistant to octylcyanoacrylate.
Results demonstrated that octylcyanoacrylate has no antibacterial activity against CSPA and CRPA.
耐环丙沙星铜绿假单胞菌（CRPA）耳漏病例数一直在稳步增加；这是一个日益受到关注的医学问题。对于儿童耳科手术，氰基丙烯酸辛酯可作为手术切口闭合的替代方法。最近的体外研究表明，氰基丙烯酸辛酯作为抗菌屏障是有效的。迄今为止，关于氰基丙烯酸辛酯对CRPA抗菌作用的报道很少。本研究的目的是确定氰基丙烯酸辛酯对从慢性化脓性中耳炎患者分离出的CRPA的抗菌作用。
从患者中获取临床CRPA（n = 20）细菌和环丙沙星敏感的铜绿假单胞菌（CSPA）（n = 20）。通过纸片扩散法测定对各种抗生素的敏感性。
CSPA和CRPA均对氰基丙烯酸辛酯耐药。
结果表明，氰基丙烯酸辛酯对CSPA和CRPA没有抗菌活性。
