多瘤病毒在成年期感染的小鼠体内的持续情况与在新生期感染的小鼠体内观察到的情况不同。
Persistence of polyomavirus in mice infected as adults differs from that observed in mice infected as newborns.
作者信息
Berke Z, Dalianis T
机构信息
Department of Clinical Virology, Karolinska Institute, Stockholm County Council, Sweden.
出版信息
J Virol. 1993 Jul;67(7):4369-71. doi: 10.1128/JVI.67.7.4369-4371.1993.
Abstract
By using the polymerase chain reaction (PCR) technique, a technique more sensitive than Southern analysis, which allows detection of polyomavirus DNA only in newborn and nude adult mice, it has now been possible to monitor the persistence pattern of polyomavirus DNA after infection of normal adult CBA mice for the first time. Viral signs appeared gradually, showing variations in time course and organ distribution between mice, and reached a peak activity after 2 to 3 weeks, when they could be found in bone, heart, gonads, lymph node, and skin, but disappeared by 2 to 5 months. No virus DNA was detected in the kidneys or lungs, which is in contrast to what is observed after infection of newborn mice. This finding suggests that the persistence pattern of polyomavirus is age dependent.
摘要
通过使用聚合酶链反应（PCR）技术，一种比Southern分析更灵敏的技术（后者仅能在新生小鼠和成年裸鼠中检测到多瘤病毒DNA），现在首次有可能监测正常成年CBA小鼠感染多瘤病毒DNA后的持续模式。病毒迹象逐渐出现，在不同小鼠之间呈现出时间进程和器官分布的差异，并在2至3周后达到活动高峰，此时在骨骼、心脏、性腺、淋巴结和皮肤中均可发现病毒迹象，但在2至5个月后消失。在肾脏或肺部未检测到病毒DNA，这与新生小鼠感染后的情况形成对比。这一发现表明多瘤病毒的持续模式与年龄有关。
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