Bardelas J A, Winkelstein J A, Seto D S, Tsai T, Rogol A D
J Pediatr. 1977 Mar;90(3):396-99. doi: 10.1016/s0022-3476(77)80700-2.
Patients with deficient antibody-mediated immunity may develop a rare "dermatomyositis-like" syndrome, which is usually progressive and fatal. We have observed a child with hypogammaglobulinemia in whom a dermatomyositis-like syndrome was associated with a fatal, disseminated ECHO 24 infection. This association suggests that in some immunodeficient patients the fatal dermatomyositis-like syndrome is a manifestation of a viral infection in a compromised host. The use of maternal plasma, with a high titer of ECHO 24 neutralizing activity, was unsuccessful in arresting the progress of the infection.
抗体介导免疫缺陷的患者可能会发展出一种罕见的“皮肌炎样”综合征，通常呈进行性且致命。我们观察到一名患有低丙种球蛋白血症的儿童，其皮肌炎样综合征与致命的播散性埃可病毒24型感染相关。这种关联表明，在一些免疫缺陷患者中，致命的皮肌炎样综合征是病毒在免疫功能受损宿主中感染的一种表现。使用具有高滴度埃可病毒24型中和活性的母体血浆未能阻止感染的进展。
