Nugent K P, Talbot I C, Hodgson S V, Phillips R K
Department of Pathology, St. Marks Hospital, London, England.
Gastroenterology. 1993 Sep;105(3):698-700. doi: 10.1016/0016-5085(93)90885-g.
Solitary juvenile polyps are considered benign. In contrast, juvenile polyposis is associated with malignancy and poor long-term outcome. Recent reports suggest that solitary juvenile polyps may also undergo both adenomatous and malignant change. The long-term outcome of patients with solitary juvenile polyps is unknown. Patients are treated conservatively and discharged from follow-up. The present study was designed to examine the incidence of cancer and mortality of these patients, comparing their life expectancy with that of the general population.
The outcome of 82 patients with a solitary juvenile polyp between 1958 and 1982 was examined by life table analysis. Patients were traced through the Office of Population Censuses and Surveys for death and cancer registration. Patients were compared with an age- and sex-matched group of the general population.
The relative risk of dying for patients who have previously had a solitary juvenile polyp in comparison with the general population was found to be 0.66 (95% confidence interval, 0.34-1.14). There was only one case of colorectal cancer.
Patients with a solitary juvenile polyp are not at increased risk of dying of or developing colorectal cancer and do not require further follow-up or investigations.
孤立性幼年息肉被认为是良性的。相比之下，幼年息肉病与恶性肿瘤及不良的长期预后相关。近期报告提示，孤立性幼年息肉也可能发生腺瘤性及恶性改变。孤立性幼年息肉患者的长期预后尚不清楚。患者接受保守治疗并停止随访。本研究旨在检查这些患者的癌症发生率及死亡率，并将其预期寿命与普通人群进行比较。
采用寿命表分析对1958年至1982年间82例孤立性幼年息肉患者的预后进行检查。通过人口普查和调查办公室追踪患者的死亡及癌症登记情况。将患者与年龄和性别匹配的普通人群组进行比较。
发现既往有孤立性幼年息肉的患者与普通人群相比，死亡的相对风险为0.66（95%置信区间，0.34 - 1.14）。仅1例结直肠癌。
孤立性幼年息肉患者死于或发生结直肠癌的风险未增加，无需进一步随访或检查。
