Stinson M W, Levine M J
Department of Microbiology, School of Medicine and Biomedical Sciences, State University of New York, Buffalo 14214.
Crit Rev Oral Biol Med. 1993;4(3-4):309-14. doi: 10.1177/10454411930040030801.
Porphyromonas gingivalis adheres in vitro to biofilms containing Streptococcus and Actinomyces species. On initial entry to the mouth, this interbacterial adhesion may enable P. gingivalis to colonize dental plaque and to avoid clearance by saliva flow. Saliva may also interfere directly with P. gingivalis colonization of dental plaque; a 43-kDa glycoprotein in human submandibular-sublingual saliva binds to P. gingivalis surfaces and diminishes interbacterial adhesion activity. To avoid fouling of its surface by host components, P. gingivalis produces surface-localized proteases that can degrade adsorbed proteins and may serve to unmask bacterial adhesins. Successful management of P. gingivalis colonization might be achieved in the future by devising artificial methods to block its surface adhesins or to prevent bacterial proteolysis of native salivary molecules that have protective functions.
牙龈卟啉单胞菌在体外可黏附于含有链球菌和放线菌属的生物膜。初次进入口腔时，这种细菌间的黏附可能使牙龈卟啉单胞菌在牙菌斑中定植，并避免被唾液冲走。唾液也可能直接干扰牙龈卟啉单胞菌在牙菌斑中的定植；人下颌下-舌下唾液中的一种43 kDa糖蛋白可与牙龈卟啉单胞菌表面结合，并降低细菌间的黏附活性。为避免宿主成分污染其表面，牙龈卟啉单胞菌产生可降解吸附蛋白的表面定位蛋白酶，这些蛋白酶可能有助于暴露细菌黏附素。未来，通过设计人工方法阻断其表面黏附素或防止具有保护功能的天然唾液分子被细菌蛋白水解，或许能够成功控制牙龈卟啉单胞菌的定植。
