van der Meulen J, Verhoeven M C, Koerten H K
Laboratory for Electron Microscopy, University of Leiden, The Netherlands.
Eur J Morphol. 1993 Mar-Jun;31(1-2):9-12.
The peritoneal cavity of mice was used as a compartment to investigate the inflammatory activity and degradation of three types of calcium phosphate ceramic in granulated form. The granules used were spherical shaped, without significant difference in average size. The spheres consisted of hydroxyapatite (HA), B-tricalcium phosphate (TCP), or fluorapatite (FA). Suspensions of each type of ceramic were injected intraperitoneally. This injection gave a mild inflammatory reaction as judged by the influx of neutrophil granulocytes. With respect to this parameter no significant difference between the injected ceramics was found. After two days the number of neutrophil granulocytes has returned to the normal level. Within two days the injected spheres accumulated in aggregates. The amount of fibrous tissue, present in the aggregates varied per type of ceramic. Degradation of the spheres was studied as well. It was found that the rate of degradation differed for each type, TCP shows a rapid and linear degradation up to 32 days, whereas HA and FA degraded much slower.
以小鼠腹腔作为一个腔室，研究三种颗粒状磷酸钙陶瓷的炎症活性和降解情况。所用颗粒为球形，平均尺寸无显著差异。这些球体由羟基磷灰石（HA）、β-磷酸三钙（TCP）或氟磷灰石（FA）组成。将每种陶瓷的悬浮液腹腔注射。通过中性粒细胞的流入判断，这种注射引起了轻微的炎症反应。就该参数而言，未发现注射的陶瓷之间存在显著差异。两天后，中性粒细胞数量已恢复到正常水平。两天内，注射的球体聚集在一起。聚集体中存在的纤维组织量因陶瓷类型而异。还研究了球体的降解情况。发现每种类型的降解速率不同，TCP在长达32天的时间内呈现快速线性降解，而HA和FA降解则慢得多。
