Wiśniewski K, Borawska M, Car H
Department of Pharmacology, Medical Academy, Białystok, Poland.
Pol J Pharmacol. 1993 Jan-Feb;45(1):23-9.
Angiotensin II(1-8) (A II) and its fragments: angiotensin III(2-8) (A III), angiotensin IV(3-8) (AIV), angiotensin V (4-8) (A V) and angiotensin VI(3-7) (A VI) accelerate acquisition of avoidance response and prolong their extinction. A II fragments are devoid classical A II activities such as the effects on blood pressure and thirst. Alcohol administered chronically (for 9 weeks) depresses the ability to retrieve and acquire avoidance responses. The investigated A II fragments counteract the post-alcohol impairment of learning and memory processes (A V being somewhat less active). Fragments A IV and A VI normalize the retrieval in offspring of mothers exposed to alcohol pre- and post-natally.
血管紧张素II（1-8）（A II）及其片段：血管紧张素III（2-8）（A III）、血管紧张素IV（3-8）（AIV）、血管紧张素V（4-8）（A V）和血管紧张素VI（3-7）（A VI）可加速回避反应的获得并延长其消退时间。A II片段缺乏经典的A II活性，如对血压和口渴的影响。长期（9周）给予酒精会抑制获取和检索回避反应的能力。所研究的A II片段可抵消酒精对学习和记忆过程的损害（A V的活性稍低）。A IV和A VI片段可使产前和产后暴露于酒精的母亲的后代的检索功能恢复正常。
