Barthold S W
Lab Anim Sci. 1980 Apr;30(2 Pt 1):167-73.
The relationship of Citrobacter freundii (4280) to the development of colonic hyperplasia in mice was investigated. The number of Citrobacter freundii (4280) in the descending colon were quantitated at intervals following experimental inoculation, and findings were correlated with previously reported histological and ultrastructural findings. Citrobacter freundii (4280) was a transient infection, lasting 2-3 weeks, after which time mice no longer harbored the organism. Neomycin sulfate and tetracycline hydrochloride, when administered in the drinking water, were useful in the prevention of infection as well as ablation of established infection. The presence of Citrobacter freundii (4280) for as little as 2 days was sufficient stimulus to result in detectable mucosal hyperplasia. The longer the bacterium was present, through 10 days, the greater the hyperplasia.
研究了弗氏柠檬酸杆菌（4280）与小鼠结肠增生发展之间的关系。在实验接种后的不同时间间隔，对降结肠中的弗氏柠檬酸杆菌（4280）数量进行定量，并将结果与先前报道的组织学和超微结构结果相关联。弗氏柠檬酸杆菌（4280）是一种短暂感染，持续2 - 3周，此后小鼠不再携带该菌。硫酸新霉素和盐酸四环素通过饮水给药，对预防感染以及消除已建立的感染很有用。弗氏柠檬酸杆菌（4280）仅存在2天就足以刺激导致可检测到的黏膜增生。细菌存在的时间越长，直至10天，增生就越严重。
