Wong W W, Hachey D L, Insull W, Opekun A R, Klein P D
USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX.
J Lipid Res. 1993 Aug;34(8):1403-11.
The fractional synthesis rate (FSR) of cholesterol was measured in 6 breast-fed and 12 formula-fed infants (ages 4 to 5 months) using the 2H2O method. The breast-fed infants had higher cholesterol intakes (18.2 +/- 4.0 vs. 3.4 +/- 1.8 mg/kg per day, P = 0.001), plasma total cholesterol (183 +/- 47 vs. 112 +/- 22 mg/dl, P = 0.013), and plasma low density lipoprotein (LDL)-cholesterol (83 +/- 26 vs. 48 +/- 16 mg/day, P = 0.023) than the formula-fed infants (6.9 +/- 2.6 vs. 2.1 +/- 0.6%/day, P < 0.001). Among all infants, there was a significant inverse relationship (P = 0.002, r = 0.66) between the FSR of cholesterol and dietary cholesterol intake. Our findings indicate that the greater cholesterol intake of the breast-fed infants was associated with elevated plasma LDL-cholesterol concentrations and that cholesterol synthesis in human infants may be efficiently regulated via HMG-CoA reductase when infants are challenged with high intakes of dietary cholesterol.
采用2H2O法对6名母乳喂养和12名配方奶喂养的婴儿（4至5个月龄）进行了胆固醇的分数合成率（FSR）测定。母乳喂养的婴儿胆固醇摄入量更高（18.2±4.0 vs. 3.4±1.8毫克/千克/天，P = 0.001），血浆总胆固醇水平更高（183±47 vs. 112±22毫克/分升，P = 0.013），血浆低密度脂蛋白（LDL）-胆固醇水平更高（83±26 vs. 48±16毫克/天，P = 0.023），其FSR也高于配方奶喂养的婴儿（6.9±2.6 vs. 2.1±0.6%/天，P < 0.001）。在所有婴儿中，胆固醇的FSR与膳食胆固醇摄入量之间存在显著的负相关关系（P = 0.002，r = 0.66）。我们的研究结果表明，母乳喂养婴儿较高的胆固醇摄入量与血浆LDL-胆固醇浓度升高有关，并且当婴儿摄入高膳食胆固醇时，人类婴儿体内的胆固醇合成可能通过HMG-CoA还原酶得到有效调节。
