Zeller H, Novak P, Landgraf R
Institut für Physikalische Medizin, Baden-Baden--West-Germany.
Int J Artif Organs. 1989 Feb;12(2):129-35.
For the development of an implantable artificial endocrine pancreas, a sensor for blood glucose measurement is needed providing a long-term stability. This goal can be achieved by the application of infrared spectroscopy which, unlike electrochemical sensors, responds directly to the glucose molecule. An investigation under physiological conditions revealed five glucose absorption bands in the near and middle infrared range. These are 1040, 1085, 1109, 1160 and 1365 cm-1. Only the 1040 cm-1 frequency coincides with none of the other infrared-active blood substances like proteins, lipids and urea. Nevertheless, the other absorption bands too, especially the 1109 cm-1 frequency, can be used for blood glucose measurement, if the superimposed absorptions are compensated. Methods for the compensation have been found. Technically feasible embodiments of an infrared glucose sensor are described.
为了开发可植入式人工内分泌胰腺，需要一种能够提供长期稳定性的血糖测量传感器。通过应用红外光谱法可以实现这一目标，与电化学传感器不同，红外光谱法能直接对葡萄糖分子做出反应。在生理条件下的一项研究揭示了近红外和中红外范围内的五个葡萄糖吸收带。它们分别是1040、1085、1109、1160和1365厘米-1。只有1040厘米-1的频率与蛋白质、脂质和尿素等其他红外活性血液物质的频率均不重合。然而，如果对叠加吸收进行补偿，其他吸收带，尤其是1109厘米-1的频率，也可用于血糖测量。已经找到了补偿方法。文中描述了红外葡萄糖传感器在技术上可行的实施方案。
