在卡介苗接种的豚鼠中通过血清或血液转移来增强结核菌素皮肤反应的尝试。
Attempts to boost tuberculin skin reactions by serum or blood transfer in BCG-vaccinated guinea-pigs.
作者信息
Lehmann E H
出版信息
Scand J Respir Dis. 1977;58(1):27-32.
PMID:841292
Abstract
In persons with waning sensitivity to mycobacterial antigens, skin reactivity to tuberculin may be maintained or enhanced as a result of tuberculin testing. Similar phenomena have been observed in guinea-pigs. As tuberculin testing may lead to antibody formation, the "booster" effect might be due to circulating antibody. However, a series of nine pilot experiments including blood and serum transfer from boosted to unboosted BCG-vaccinated guinea-pigs gave no support to this hypothesis.
摘要
在对分枝杆菌抗原敏感性逐渐降低的人群中，结核菌素皮肤反应性可能因结核菌素试验而得以维持或增强。在豚鼠中也观察到了类似现象。由于结核菌素试验可能导致抗体形成，“增强”效应可能归因于循环抗体。然而，包括将接受增强免疫的卡介苗接种豚鼠的血液和血清转移至未接受增强免疫的豚鼠在内的一系列九项初步实验并不支持这一假说。
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