Stratz T, Samborski W, Hrycaj P, Pap T, Mackiewicz S, Mennet P, Müller W
Hochrhein-Institute für Rheumaforschung und Rheumapravention, Bad Säckingen (D)/Rheinfelden (CH).
Med Klin (Munich). 1993 Aug 15;88(8):458-62.
The serum concentration of serotonin (S-5-HT) was measured in 31 patients with primary fibromyalgia, 21 patients with rheumatoid arthritis (RA) (15 of them with secondary fibromyalgia) and 20 healthy volunteers. Both patients with primary fibromyalgia and rheumatoid arthritis had significantly lower S-5-HT levels when compared to healthy controls, and S-5-HT concentrations in patients with secondary fibromyalgia were even significantly lower than those of RA-patients. Unlike the patients with rheumatoid arthritis, a significant correlation between S-5-HT level and the number of "tender points" as well as mean pressure tenderness at 24 different points was found in patients with primary fibromyalgia. Conversely, in patients with rheumatoid arthritis the S-5-HT level correlated significantly with erythrocyte sedimentation rate. These results suggest different pathological mechanisms of S-5-HT decrease in patients with primary fibromyalgia and rheumatoid arthritis. On the other hand, they raise the question whether secondary fibromyalgia may be a pathogenetically different syndrome mimicking symptomatically primary fibromyalgia.
对31例原发性纤维肌痛患者、21例类风湿关节炎（RA）患者（其中15例伴有继发性纤维肌痛）和20名健康志愿者测定了血清5-羟色胺（S-5-HT）浓度。与健康对照相比，原发性纤维肌痛患者和类风湿关节炎患者的S-5-HT水平均显著降低，继发性纤维肌痛患者的S-5-HT浓度甚至显著低于类风湿关节炎患者。与类风湿关节炎患者不同，在原发性纤维肌痛患者中发现S-5-HT水平与“压痛点”数量以及24个不同点的平均压痛之间存在显著相关性。相反，在类风湿关节炎患者中，S-5-HT水平与红细胞沉降率显著相关。这些结果提示原发性纤维肌痛患者和类风湿关节炎患者S-5-HT降低的病理机制不同。另一方面，它们提出了一个问题，即继发性纤维肌痛是否可能是一种在症状上模仿原发性纤维肌痛但发病机制不同的综合征。
