Hoek G, Fischer P, Brunekreef B, Lebret E, Hofschreuder P, Mennen M G
Department of Epidemiology, University of Wageningen, The Netherlands.
Am Rev Respir Dis. 1993 Jan;147(1):111-7. doi: 10.1164/ajrccm/147.1.111.
In the spring and summer of 1989 an epidemiologic study was conducted to evaluate the acute effects of photochemical air pollution episodes on pulmonary function of children living in three nonindustrial towns in the Netherlands. Spirometry was performed repeatedly in the schools of the children, mostly during the morning hours. Data from 533 children having more than four valid pulmonary function tests were included in the analyses. The association between previous-day ambient ozone concentration and pulmonary function was evaluated, using individual linear regression analysis and subsequent evaluation of the distribution of individual regression coefficients. One hour maximum ambient ozone concentrations frequently exceeded 160 micrograms/m3 but were all lower than the Dutch Air Quality Guideline of 240 micrograms/m3 for all three populations. Significant negative associations of previous-day ambient ozone with FVC, FEV1, peak expiratory flow (PEF), and maximal midexpiratory flow (MMEF) were observed. There were indications of systematic differences in responses among the children. Children with chronic respiratory symptoms did not have a stronger response than children without these symptoms.
1989年春夏，开展了一项流行病学研究，以评估光化学空气污染事件对荷兰三个非工业城镇儿童肺功能的急性影响。主要在上午时段，对这些儿童所在学校的学生反复进行肺活量测定。分析纳入了533名儿童的数据，这些儿童有超过四次有效的肺功能测试。采用个体线性回归分析以及随后对个体回归系数分布的评估，来评价前一天环境臭氧浓度与肺功能之间的关联。三个群体的1小时最高环境臭氧浓度经常超过160微克/立方米，但均低于荷兰空气质量指南规定的240微克/立方米。观察到前一天环境臭氧与用力肺活量（FVC）、第一秒用力呼气容积（FEV1）、呼气峰值流速（PEF）和最大呼气中期流速（MMEF）之间存在显著负相关。有迹象表明儿童之间的反应存在系统性差异。有慢性呼吸道症状的儿童与没有这些症状的儿童相比，反应并没有更强。
