Grievink L, Jansen S M, van't Veer P, Brunekreef B
Department of Epidemiology and Public Health, Wageningen Agricultural University, The Netherlands.
Occup Environ Med. 1998 Jan;55(1):13-7. doi: 10.1136/oem.55.1.13.
To identify whether acute lung function effects of ozone can be modulated by antioxidant vitamin supplementation.
Amateur cyclists (n = 26) were studied in the summer of 1994 in The Netherlands. Repeated lung function measurements were performed with a rolling seal spirometer after training sessions or competitive races on four to 14 occasions. The cyclists were assigned to two study groups. The supplementation group (n = 12) received antioxidant supplements (15 mg beta-carotene, 75 mg vitamin E, and 650 mg vitamin C) once a day for three months. The control group did not receive supplementation. For each subject, lung function after exercise was regressed on the previous eight hour mean ozone concentration. The individual regression coefficients were pooled for each study group and weighted with the inverse of the variance.
The eight hour mean ozone concentration was 101 micrograms/m3 (30 to 205 micrograms/m3). For the supplementation group, there was no effect of ozone on FVC, FEV1, peak expiratory flow (PEF), and maximal mid-expiratory flow (MMEF). For the control group the mean coefficients were negative, except for MMEF. The difference between the groups was 2.08 (95% confidence interval (95% CI) 1.31 to 2.85) ml/microgram/m3 for FVC, 1.66 (95% CI 0.62 to 2.70) for FEV1, 6.83 (95% CI 3.17 to 10.49) for PEF, and 0.42 (95% CI -1.38 to 2.22) for MMEF.
The results suggest that antioxidant vitamin supplementation protects against acute effects of ozone on lung function in heavily exercising amateur cyclists.
确定补充抗氧化维生素是否能调节臭氧对肺功能的急性影响。
1994年夏天在荷兰对业余自行车运动员（n = 26）进行了研究。在训练课程或四至十四次比赛后，使用滚动密封式肺活量计对肺功能进行重复测量。自行车运动员被分为两个研究组。补充组（n = 12）每天服用一次抗氧化补充剂（15毫克β-胡萝卜素、75毫克维生素E和650毫克维生素C），持续三个月。对照组不接受补充剂。对于每个受试者，运动后的肺功能与前八小时的平均臭氧浓度进行回归分析。将每个研究组的个体回归系数合并，并以方差的倒数加权。
八小时平均臭氧浓度为101微克/立方米（30至205微克/立方米）。对于补充组，臭氧对用力肺活量（FVC）、第一秒用力呼气容积（FEV1）、呼气峰值流速（PEF）和最大呼气中期流速（MMEF）没有影响。对于对照组，除MMEF外，平均系数均为负数。两组之间的差异为：FVC为2.08（95%置信区间（95%CI）1.31至2.85）毫升/微克/立方米，FEV1为1.66（95%CI 0.62至2.70），PEF为6.83（95%CI 3.17至10.49），MMEF为0.42（95%CI -1.38至2.22）。
结果表明，补充抗氧化维生素可防止臭氧对剧烈运动的业余自行车运动员肺功能产生急性影响。
