LoSasso T, Chui C S, Kutcher G J, Leibel S A, Fuks Z, Ling C C
Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, NY 10021.
Int J Radiat Oncol Biol Phys. 1993 Jan 15;25(2):161-70. doi: 10.1016/0360-3016(93)90337-u.
We investigate the use of a multi-leaf collimator for conformal radiation therapy of carcinomas of the prostate and of the nasopharynx. Following verification of dose calculation algorithms for multi-leaf collimated fields using film dosimetry, we compute dose distributions for multi-field conformal treatment using fields shaped with either the multi-leaf collimator or conventional cerrobend blocks. We compare the two sets of treatment plans using graphical isodose displays, tissue specific dose volume histograms, tumor control probabilities, and normal tissue complication probabilities. We also incorporate setup errors into the calculated dose distributions to assess the effect of treatment uncertainties on the various criteria. Based on these comparisons, we conclude that for multi-field conformal radiotherapy for these two disease sites, the use of multi-leaf collimation is equivalent to that of conventional cerrobend blocks.
我们研究了多叶准直器在前列腺癌和鼻咽癌适形放射治疗中的应用。在使用胶片剂量测定法验证多叶准直野的剂量计算算法之后，我们计算了使用多叶准直器或传统铅挡块成形的射野进行多野适形治疗的剂量分布。我们使用图形等剂量显示、组织特异性剂量体积直方图、肿瘤控制概率和正常组织并发症概率来比较这两组治疗计划。我们还将摆位误差纳入计算出的剂量分布中，以评估治疗不确定性对各种标准的影响。基于这些比较，我们得出结论，对于这两个疾病部位的多野适形放射治疗，使用多叶准直与使用传统铅挡块等效。
