Sussman N L, Kelly J H
Department of Medicine, Baylor College of Medicine, Houston, Texas.
Artif Organs. 1993 Jan;17(1):27-30. doi: 10.1111/j.1525-1594.1993.tb00381.x.
A 68-year-old woman with fulminant hepatic failure of unknown etiology was treated with a bioartificial liver assist device. Prior to treatment, she had a number of clinical and laboratory features that suggested a hopeless outcome. Treatment was associated with a dramatic change in her mental status, and her clinical picture improved progressively during 6 days of continuous therapy. Evidence of recovery of native liver function allowed the discontinuation of treatment, and she continued to improve for a further 3 1/2 days before her demise from septic shock. We propose that a metabolically active liver assist device is a logical and practical method for treating the critical phase of fulminant hepatic failure.
一名病因不明的暴发性肝衰竭68岁女性接受了生物人工肝辅助装置治疗。治疗前，她有许多临床和实验室特征提示预后无望。治疗与她的精神状态发生显著变化相关，在持续治疗的6天里她的临床情况逐渐改善。天然肝功能恢复的证据使得治疗得以停止，在她因感染性休克死亡前的另外3.5天里她继续好转。我们认为，一种具有代谢活性的肝辅助装置是治疗暴发性肝衰竭关键阶段的合理且实用的方法。
