Eriksson M
Department of Oncology, University Hospital, Umeå, Sweden.
Eur J Cancer. 1993;29A(2):259-63. doi: 10.1016/0959-8049(93)90188-l.
This population-based case-control investigation was designed to study the importance of rheumatoid arthritis, other diseases and different types of treatment for the risk of developing multiple myeloma. In total, 275 cases with verified myeloma in northern Sweden were matched to as many control subjects. Information about different diseases, drug use, diagnostic X-ray investigations and radiotherapy was obtained through an extensive questionnaire mailed to all living subjects, i.e. cases and controls, and to the next of kin regarding deceased subjects. The study confirmed a suspected association with both rheumatic diseases in general and rheumatoid arthritis specifically. No other disease gave an increased risk for myeloma, but on the contrary, other diseases were in general more common among the controls. In accordance with this finding, use of medications and diagnostic X-ray investigations were also less common in cases than in controls. The study did, however, give some support to a recent finding that the number of X-ray investigations might be a risk factor for myeloma. Earlier radiotherapy on benign indications was more common in cases, whereas radiotherapy for malignant disease was more common among controls in this study.
这项基于人群的病例对照研究旨在探讨类风湿性关节炎、其他疾病以及不同类型治疗方法对多发性骨髓瘤发病风险的影响。在瑞典北部，共对275例确诊骨髓瘤患者与同样数量的对照者进行了匹配。通过向所有在世的研究对象（即病例组和对照组）以及已故研究对象的近亲邮寄一份详尽的调查问卷，获取了有关不同疾病、药物使用、诊断性X线检查及放射治疗的信息。该研究证实了此前怀疑的骨髓瘤与一般风湿性疾病尤其是类风湿性关节炎之间的关联。没有其他疾病会增加骨髓瘤的发病风险，相反，其他疾病在对照组中总体上更为常见。据此发现，病例组使用药物和进行诊断性X线检查的情况也比对照组少。不过，该研究确实为近期一项发现提供了一定支持，即X线检查的次数可能是骨髓瘤的一个风险因素。在本研究中，病例组因良性指征进行的早期放疗更为常见，而对照组因恶性疾病进行放疗的情况更为常见。
