Ortmeyer H K, Huang L C, Zhang L, Hansen B C, Larner J
Department of Physiology, University of Maryland School of Medicine, Baltimore 21201.
Endocrinology. 1993 Feb;132(2):646-51. doi: 10.1210/endo.132.2.8425484.
The acute effects of administration of D-chiroinositol (D-CI), a component of a putative mediator of insulin action, on plasma glucose were examined in low dose streptozotocin-treated rats and normal rats given a glucose load and the effects on plasma glucose and insulin were determined in five obese rhesus monkeys with varying degrees of spontaneous insulin resistance. Single dose intragastric D-CI (10 mg/kg) administered to streptozotocin-treated rats produced a 30-40% decrease in plasma glucose (P < 0.05) at 30-120 min. Single dose intragastric D-CI (2-15 mg/kg) administered to normal rats 2 h before ip glucose produced a 30-50% decrease (P < 0.05) in plasma glucose. D-CI (10 mg/kg) caused a 50% increase (P < 0.05) in glucose disappearance rates in these rats. Myoinositol (10 mg/kg) was without effect. Intravenously administered single dose D-CI (100 mg/kg) increased both the glucose and insulin disappearance rates by 129 +/- 41% (mean +/- SE; P < 0.06) and 89 +/- 39% (P = 0.01), respectively, in all monkeys between 0-30 min compared to control values. D-CI administration, therefore, lowered elevated plasma glucose in streptozotocin-treated hyperglycemic rats, normal rats given a glucose load, and spontaneously insulin-resistant monkeys with or without noninsulin-dependent diabetes mellitus. Intravenous D-CI also lowered plasma insulin in these monkeys.
在低剂量链脲佐菌素处理的大鼠以及给予葡萄糖负荷的正常大鼠中，研究了胰岛素作用假定介质的一种成分D-手性肌醇（D-CI）给药对血糖的急性影响，并在五只具有不同程度自发性胰岛素抵抗的肥胖恒河猴中测定了其对血糖和胰岛素的影响。给链脲佐菌素处理的大鼠单次胃内给予D-CI（10mg/kg），在30 - 120分钟时血糖降低了30 - 40%（P < 0.05）。在腹腔注射葡萄糖前2小时给正常大鼠单次胃内给予D-CI（2 - 15mg/kg），血糖降低了30 - 50%（P < 0.05）。D-CI（10mg/kg）使这些大鼠的葡萄糖消失率提高了50%（P < 0.05）。肌醇（10mg/kg）无此作用。与对照值相比，在所有猴子中，静脉注射单次剂量的D-CI（100mg/kg）在0 - 30分钟内分别使葡萄糖和胰岛素消失率提高了129±41%（平均值±标准误；P < 0.06）和89±39%（P = 0.01）。因此，给予D-CI可降低链脲佐菌素处理的高血糖大鼠、给予葡萄糖负荷的正常大鼠以及患有或未患有非胰岛素依赖型糖尿病的自发性胰岛素抵抗猴子的升高血糖。静脉注射D-CI也降低了这些猴子的血浆胰岛素水平。
