Ortmeyer H K
Department of Physiology, School of Medicine, University of Maryland at Baltimore 21201, USA.
Obes Res. 1996 Nov;4(6):569-75. doi: 10.1002/j.1550-8528.1996.tb00271.x.
In a previous study, D-chiroinositol added to a meal (0.5 g/kg) resulted in significantly lower postprandial plasma glucose concentrations without an increase in insulin concentrations in obese insulin-resistant monkeys. The present report describes the effects of another isomer of inositol, myoinositol, on postprandial plasma glucose and insulin concentrations and on urine glucose concentrations in 6 similarly insulin-resistant monkeys. The three 5 day study periods included a control period (liquid diet ad libitum) and 2 experimental periods (liquid diet ad libitum with either 1.5 g/kg/day myoinositol or D-chiroinositol added). Twenty-four hour urine samples were collected during each 5 day period. On the sixth day of each period the monkeys were anesthetized 110 min after completing either the control meal (15 ml/kg) or the experimental meals (1.5 g/kg myoinositol or D-chiroinositol) and plasma samples were obtained at 120, 150, 180, 210, 240, 270 and 300 min. The plasma glucose concentration was lower after the meal with myoinositol compared to the control meal at 120, 150 and 180 min (p's < 0.05). The plasma insulin concentration was lower after the meal with myoinositol compared to the control meal at 150 and 180 min (p's < 0.05). In addition, 24 hour urine glucose concentrations were lower during the myoinositol diet compared to the control diet (p < 0.001). The plasma glucose concentration was lower after the meal with D-chiroinositol compared to the control meal at 150, 240, 270 and 300 min (p's < or = 0.05). In obese insulin-resistant monkeys, myoinositol added to the diet lowers urine glucose concentrations and both myoinositol and D-chiroinositol added to a meal lower postprandial plasma glucose concentrations without increasing postprandial insulin concentrations. Therefore, myoinositol, like D-chiroinositol, may be a useful agent for reducing meal-induced hyperglycemia without inducing hyperinsulinemia in insulin-resistant subjects.
在之前的一项研究中，给肥胖的胰岛素抵抗猴子的一餐中添加D-手性肌醇（0.5克/千克），可使餐后血浆葡萄糖浓度显著降低，而胰岛素浓度并未升高。本报告描述了肌醇的另一种异构体——肌醇对6只类似胰岛素抵抗猴子的餐后血浆葡萄糖和胰岛素浓度以及尿葡萄糖浓度的影响。三个为期5天的研究阶段包括一个对照期（随意进食流质饮食）和两个实验期（随意进食添加了1.5克/千克/天肌醇或D-手性肌醇的流质饮食）。在每个5天期间收集24小时尿液样本。在每个阶段的第6天，猴子在吃完对照餐（15毫升/千克）或实验餐（1.5克/千克肌醇或D-手性肌醇）110分钟后麻醉，在120、150、180、210、240、270和300分钟采集血浆样本。与对照餐相比，在120、150和180分钟时，食用肌醇餐后的血浆葡萄糖浓度较低（p值<0.05）。在150和180分钟时，与对照餐相比，食用肌醇餐后的血浆胰岛素浓度较低（p值<0.05）。此外，与对照饮食相比，在肌醇饮食期间24小时尿葡萄糖浓度较低（p<0.001）。与对照餐相比，在150、240、270和300分钟时，食用D-手性肌醇餐后的血浆葡萄糖浓度较低（p值≤0.05）。在肥胖的胰岛素抵抗猴子中，饮食中添加肌醇可降低尿葡萄糖浓度，餐中添加肌醇和D-手性肌醇均可降低餐后血浆葡萄糖浓度，而不会增加餐后胰岛素浓度。因此，肌醇与D-手性肌醇一样，可能是一种有用的药物，可在不引起胰岛素抵抗受试者高胰岛素血症的情况下降低餐食诱导的高血糖。
