Ortmeyer H K, Larner J, Hansen B C
Department of Physiology, University of Maryland School of Medicine, Baltimore, 21201, USA.
Obes Res. 1995 Nov;3 Suppl 4:605S-608S. doi: 10.1002/j.1550-8528.1995.tb00232.x.
We have previously demonstrated that D-chiroinositol, administered intravenously to insulin-resistant monkeys, increases the rate of disappearance of plasma glucose and insulin. The purpose of the present study was to determine whether orally administered D-chiroinositol might also similarly improve the postprandial plasma glucose profile of hyperinsulinemic insulin-resistant monkeys. A complete liquid diet meal (15 ml/kg body weight) was ingested by each of six monkeys on two occasions separated by 10 days, with conditions identical except D-chiroinositol (500 mg/kg body weight) was added to the second meal. At 110 minutes following each meal, the monkeys were anesthetized and blood samples obtained at 120, 150, 180, 210, 240, 270 and 300 minutes. Plasma glucose and insulin concentrations were determined. The mean plasma glucose concentration (120-300 minutes) was significantly lower after the meal containing D-chiroinositol compared to the control meal (7.1 +/- 1.2 vs. 7.8 +/- 1.2 mM) (p < 0.05). Plasma insulin concentrations tended to be lower after the meal containing D-chiroinositol compared to the control meal (3930 +/- 1068 vs. 4518 +/- 1200 pM) (p < 0.15, ns). We conclude that in hyperinsulinemic monkeys, D-chiroinositol added to a meal lowers postprandial plasma glucose without an increase in plasma insulin, and therefore may be a useful agent for reducing meal-induced hyperglycemia without inducing hyperinsulinemia.
我们之前已经证明，给胰岛素抵抗的猴子静脉注射D-手性肌醇，可提高血浆葡萄糖和胰岛素的消失率。本研究的目的是确定口服D-手性肌醇是否也能同样改善高胰岛素血症胰岛素抵抗猴子的餐后血浆葡萄糖水平。六只猴子在两次间隔10天的情况下分别摄入一顿完整的流质饮食餐（15毫升/千克体重），除了在第二餐中添加D-手性肌醇（500毫克/千克体重）外，其他条件相同。每餐进食110分钟后，将猴子麻醉，并在120、150、180、210、240、270和300分钟采集血样。测定血浆葡萄糖和胰岛素浓度。与对照餐相比，含有D-手性肌醇的餐后平均血浆葡萄糖浓度（120 - 300分钟）显著降低（7.1±1.2对7.8±1.2毫摩尔）（p < 0.05）。与对照餐相比，含有D-手性肌醇的餐后血浆胰岛素浓度有降低的趋势（3930±1068对4518±1200皮摩尔）（p < 0.15，无显著性差异）。我们得出结论，在高胰岛素血症猴子中，餐中添加D-手性肌醇可降低餐后血浆葡萄糖水平，而不会增加血浆胰岛素水平，因此可能是一种有用的药物，可减少餐食诱导的高血糖而不诱导高胰岛素血症。
