强直性脊柱炎HLA-B27阳性与阴性患者的差异：临床疾病活动度及血清IgA、C反应蛋白和触珠蛋白浓度的研究
Differences in HLA-B27 positive and negative patients with ankylosing spondylitis: study of clinical disease activity and concentrations of serum IgA, C reactive protein, and haptoglobin.
作者信息
Reynolds T L, Khan M A, van der Linden S, Cleveland R P
机构信息
Case Western Reserve University, Department of Medicine, Cleveland, OH.
出版信息
Ann Rheum Dis. 1991 Mar;50(3):154-7. doi: 10.1136/ard.50.3.154.
To find out whether disease activity and B27 status were associated with serum concentrations of IgA, C reactive protein (CRP), and haptoglobin in ankylosing spondylitis (AS) multivariate analysis of variance was used to study 101 patients with AS whose disease was clinically classified as active or inactive, and who were HLA-B27 typed. It was found that B27 and disease activity do interact significantly to affect the serum concentrations of IgA, CRP, and haptoglobin. When the 77 B27+ patients were examined, however, it was found that disease activity was significantly associated with serum concentrations IgA. In contrast, in the 24 B27- patients concentrations of serum IgA were significantly associated with disease activity, but not. These results emphasise the known difference between B27+ and B27- AS and suggest different pathogenic mechanisms in the two forms of AS.
为了探究疾病活动度和B27状态是否与强直性脊柱炎（AS）患者血清中IgA、C反应蛋白（CRP）及触珠蛋白的浓度相关，我们运用多因素方差分析对101例AS患者进行研究，这些患者的疾病在临床上被分类为活动期或非活动期，且均进行了HLA - B27分型。结果发现，B27与疾病活动度确实存在显著相互作用，从而影响血清中IgA、CRP及触珠蛋白的浓度。然而，在对77例B27阳性患者进行检查时发现，疾病活动度与血清IgA浓度显著相关。相比之下，在24例B27阴性患者中，血清IgA浓度与疾病活动度虽有关联，但并不显著。这些结果强调了已知的B27阳性和B27阴性AS之间的差异，并提示两种形式的AS存在不同的致病机制。
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