Mapou R L, Law W A, Martin A, Kampen D, Salazar A M, Rundell J R
Henry M. Jackson Foundation for the Advancement of Military Medicine, Military Medical Consortium for Applied Retroviral Research, Rockville, Maryland 20850.
J Neuropsychiatry Clin Neurosci. 1993 Winter;5(1):86-93. doi: 10.1176/jnp.5.1.86.
Seventy-nine military medical beneficiaries infected with human immunodeficiency virus (HIV+) and 27 HIV-seronegative control subjects (HIV-) completed a neuropsychological evaluation and a semistructured interview inquiring about difficulties in function. More HIV+ than HIV- subjects reported difficulties. HIV+ subjects reporting difficulties were significantly more likely to be deficient on attention, response speed, motor function, and memory than those not reporting difficulties. Findings for early-stage HIV+ subjects were similar. HIV+ individuals who complained of difficulties reported depression and anxiety symptoms significantly more frequently than those who did not complain, but these symptoms were not related to neuropsychological performance. Complaints of difficulties by HIV+ individuals may reflect either actual neuropsychological deficiency or mood disturbance, but the effects of each appear to be independent.
79名感染人类免疫缺陷病毒（HIV阳性）的军队医疗受益者和27名HIV血清阴性对照者（HIV阴性）完成了一项神经心理学评估和一次关于功能障碍的半结构化访谈。报告有功能障碍的HIV阳性者比HIV阴性者更多。报告有功能障碍的HIV阳性者在注意力、反应速度、运动功能和记忆力方面比未报告有功能障碍的人更明显地存在缺陷。早期HIV阳性受试者的结果相似。抱怨有功能障碍的HIV阳性个体比没有抱怨的个体更频繁地报告有抑郁和焦虑症状，但这些症状与神经心理学表现无关。HIV阳性个体对功能障碍的抱怨可能反映了实际的神经心理学缺陷或情绪障碍，但每种情况的影响似乎是独立的。
