γ纤维蛋白原基因（FGG）在牛和羊中均定位于17号染色体。

The gamma fibrinogen gene (FGG) maps to chromosome 17 in both cattle and sheep.

作者信息

Johnson S E, Barendse W, Hetzel D J

机构信息

CSIRO, Division of Tropical Animal Production, University of Queensland, Australia.

出版信息

Cytogenet Cell Genet. 1993;62(2-3):176-80. doi: 10.1159/000133466.

DOI:10.1159/000133466

PMID:8428520

Abstract

The gamma fibrinogen gene (FGG) was localised in both cattle and sheep using in situ hybridisation. The probe employed was a 1-kb bovine cDNA fragment. Based on observations of QFQ-banded chromosome preparations, this locus is on bovine chromosome 17q12-->q13 and on the homologous sheep chromosome 17. This localisation is, to our knowledge, the first assignment to chromosome 17 in either the bovine or ovine genome. In addition to localising FGG to this chromosome, the assignment provisionally maps the previously unassigned syntenic group U23, containing (besides FGG) the genes for mitochondrial aldehyde dehydrogenase 2 (ALDH2), interleukin 2 (IL2), immunoglobulin lambda (IGL), and beta fibrinogen (FGB), to chromosome 17 in cattle and probably to the same chromosome in sheep.

摘要

利用原位杂交技术在牛和羊中定位了γ纤维蛋白原基因（FGG）。所用探针是一个1 kb的牛cDNA片段。基于对QFQ带型染色体标本的观察，该基因座位于牛的17号染色体q12→q13区域以及绵羊的同源染色体17上。据我们所知，这一定位是FGG基因在牛或羊基因组中首次被定位到17号染色体上。除了将FGG基因定位到该染色体外，这一结果还初步将之前未定位的同线群U23（除FGG外，还包含线粒体醛脱氢酶2（ALDH2）、白细胞介素2（IL2）、免疫球蛋白λ（IGL）和β纤维蛋白原（FGB）基因）定位到牛的17号染色体上，并且可能也定位到绵羊的同一条染色体上。