Rojanapongpun P, Drance S M
Department of Ophthalmology, Faculty of Medicine, University of British Columbia, Vancouver, Canada.
Am J Ophthalmol. 1993 Feb 15;115(2):174-80. doi: 10.1016/s0002-9394(14)73921-2.
Transcranial Doppler ultrasound (2 MHz) was used to measure ophthalmic arterial blood flow velocity in 60 normal subjects whose mean age (+/- standard deviation) was 54.9 +/- 17.3 years (30 women, mean age, 56.3 +/- 17.5 years and 30 men, mean age, 53.5 +/- 17.3 years). Three or more measurements were recorded from each eye at reference depths of 40 to 45 mm. The peak systolic flow velocity was 45.1 +/- 7.8 cm/sec, mean-enveloped flow velocity was 22.6 +/- 5.1 cm/sec, end diastolic flow velocity was 12.0 +/- 3.4 cm/sec, pulsatility index was 1.5 +/- 0.4, and resistivity index was 0.7 +/- 0.1. No significant differences of flow variables were found between genders. Statistically significant age-related losses of mean-enveloped flow velocity and end diastolic flow velocity were shown (P = .003 and .038). There were no significant differences of flow velocities between right and left eyes when comparing means. Differences greater than 20% between eyes were found in ten subjects (16.7%) for peak systolic flow velocity, in 18 subjects (30.4%) for mean-enveloped flow velocity, and in 21 subjects (34.8%) for end diastolic flow velocity, but resistivity indexes were comparable in all cases. Ten subjects had flow velocities measured at two different depths separated by 10 mm (40 to 45 mm vs 50 to 55 mm) in the same orbit and showed that peak systolic flow velocity and mean-enveloped flow velocity were significantly higher (P = .006 and .021) at the greater depth. Recognizable differences in shape of the spectrograms obtained from the younger subjects (< or = 30 years) and the older subjects (> or = 70 years) were found.
采用经颅多普勒超声（2兆赫）对60名正常受试者的眼动脉血流速度进行测量，这些受试者的平均年龄（±标准差）为54.9±17.3岁（30名女性，平均年龄56.3±17.5岁；30名男性，平均年龄53.5±17.3岁）。在40至45毫米的参考深度对每只眼睛进行三次或更多次测量。收缩期峰值流速为45.1±7.8厘米/秒，平均包络流速为22.6±5.1厘米/秒，舒张末期流速为12.0±3.4厘米/秒，搏动指数为1.5±0.4，阻力指数为0.7±0.1。未发现血流变量在性别之间存在显著差异。显示出平均包络流速和舒张末期流速与年龄相关的统计学显著下降（P = 0.003和0.038）。比较平均值时，左右眼的流速没有显著差异。10名受试者（16.7%）的收缩期峰值流速、18名受试者（30.4%）的平均包络流速、21名受试者（34.8%）的舒张末期流速在两眼之间差异大于20%，但所有情况下阻力指数具有可比性。10名受试者在同一眼眶内两个相隔10毫米的不同深度（40至45毫米与50至55毫米）测量了流速，结果显示在较大深度处收缩期峰值流速和平均包络流速显著更高（P = 0.006和0.021）。发现从较年轻受试者（≤30岁）和较年长受试者（≥70岁）获得的频谱图形状存在可识别的差异。
