Petrozzi J W, Kaidbey K M, Kligman A M
Arch Dermatol. 1977 Mar;113(3):292-6.
Thirty patients with recalcitrant psoriasis were treated with topical methoxsalen and blacklight (UVA). A 1% concentration either in an acetone, alcohol, propylene glycol vehicle, or hydrophilic ointment, USP, applied two hours before light exposure was highly effective. Twelve patients were completely cleared and nine were markedly improved in three to five weeks. Plaque-type and guttate psoriasis responded best while exfoliative psoriasis benefitted less. Maintenance of a phototoxic reaction in the lesion was necessary for total resolution. Topical methoxsalen and blacklight is feasible for outpatient treatment of plaque-type psoriasis of limited extent.
30例顽固性银屑病患者接受了外用甲氧沙林及黑光（UVA）治疗。在光照前两小时涂抹浓度为1%的甲氧沙林，其载体为丙酮、酒精、丙二醇或美国药典规定的亲水性软膏，疗效显著。12例患者在三至五周内完全治愈，9例明显改善。斑块型和点滴状银屑病反应最佳，而剥脱性银屑病受益较少。皮损处维持光毒性反应是完全消退的必要条件。外用甲氧沙林及黑光对于门诊治疗局限性斑块型银屑病是可行的。
