Kalra S, Crank P, Hepworth J, Pickering C A, Woodcock A A
Department of Microbiology, Wythenshawe Hospital, Manchester.
Thorax. 1993 Jan;48(1):10-3. doi: 10.1136/thx.48.1.10.
Various methods of killing the house dust mite to reduce exposure to allergen are being promoted even though complete data on their effects on allergen concentrations are not available. A study was designed to measure the concentrations of the main house dust mite allergen Der pI in homes treated with either solidified benzyl benzoate (Acarosan) or liquid nitrogen.
Der pI concentrations were measured in dust collected from mattresses, bedroom carpets, and living room carpets in 10 houses treated with Acarosan and 10 houses treated with liquid nitrogen. Samples were collected before the treatment (in July 1990) and three and six months afterwards (October 1990 and January 1991). Forty untreated houses were concurrently sampled as controls.
Der pI concentrations were similar in the three groups at baseline. No significant fall was seen in either of the two treated groups three or six months after treatment. Concentrations in the control houses increased significantly--twofold to threefold in dust sampled from mattresses and bedroom carpets between baseline and October 1990. This increase was not seen in either of the treated groups of houses, but there was no significant difference in the Derp pI concentrations in these houses and the control houses from any site at any time point.
Neither Acarosan nor liquid nitrogen reduced the concentrations of Der pI for as long as six months after application. A small effect was probably present as the rise seen in control houses in the three month samples was not found in the treated houses. This effect, however, is likely to be of little clinical importance and also to be transient as the trend was lost by six months.
尽管尚无关于各种杀死屋尘螨以减少过敏原暴露方法对过敏原浓度影响的完整数据，但这些方法仍在推广。本研究旨在测量用固化苯甲酸苄酯（Acarosan）或液氮处理过的房屋中主要屋尘螨过敏原Der pI的浓度。
在10所用Acarosan处理的房屋和10所用液氮处理的房屋中，测量从床垫、卧室地毯和客厅地毯收集的灰尘中的Der pI浓度。在处理前（1990年7月）以及处理后三个月和六个月（1990年10月和1991年1月）采集样本。同时对40所未处理房屋进行采样作为对照。
三组在基线时Der pI浓度相似。处理后三个月或六个月，两个处理组中均未观察到显著下降。对照房屋中的浓度显著增加——从基线到1990年10月，床垫和卧室地毯采集的灰尘中增加了两倍至三倍。在处理过的房屋组中均未观察到这种增加，但在这些房屋和对照房屋的任何时间点，任何部位的Der pI浓度均无显著差异。
Acarosan和液氮在应用后长达六个月的时间内均未降低Der pI的浓度。可能存在微小影响，因为在处理过的房屋中未发现对照房屋三个月样本中出现的升高情况。然而，这种影响可能在临床上不太重要，而且可能是短暂的，因为到六个月时这种趋势就消失了。
