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表现为儿童复发性腮腺炎的自身免疫性外分泌腺病。

Autoimmune exocrinopathy presenting as recurrent parotitis of childhood.

作者信息

Hearth-Holmes M, Baethge B A, Abreo F, Wolf R E

机构信息

Department of Medicine, Louisiana State University Medical Center, Shreveport 71130-3932.

出版信息

Arch Otolaryngol Head Neck Surg. 1993 Mar;119(3):347-9. doi: 10.1001/archotol.1993.01880150103015.

DOI:10.1001/archotol.1993.01880150103015
PMID:8435176
Abstract

OBJECTIVE

To describe a case of autoimmune exocrinopathy in a child at the age of 3 months who presented with the original diagnosis of recurrent parotitis.

DESIGN

This a case report of a 9-year-old girl with recurrent parotitis who was later found to have Sjögren's syndrome. The literature relating to primary Sjögren's syndrome in the pediatric population is reviewed.

SETTING

The patient was seen in the rheumatology and otolaryngology clinics at a university medical center.

INTERVENTIONS

This study did not address therapy.

MAIN OUTCOME MEASURE

Diagnosis of Sjögren's syndrome.

RESULTS

The patient had xerostomia, an abnormal result of a salivary gland biopsy, SSA and SSB antibodies, and the histocompatibility antigens HLA-B8 and HLA-DR3 that are associated with Sjögren's syndrome.

CONCLUSION

Primary Sjögren's syndrome should be considered in cases of recurrent parotitis of childhood. More studies are needed to assess the natural history of autoimmune exocrinopathy in children.

摘要

目的

描述一名3个月大儿童的自身免疫性外分泌腺病病例,该患儿最初诊断为复发性腮腺炎。

设计

这是一例9岁复发性腮腺炎女孩的病例报告,该女孩后来被发现患有干燥综合征。回顾了与儿科原发性干燥综合征相关的文献。

背景

患者在大学医学中心的风湿病科和耳鼻喉科门诊就诊。

干预措施

本研究未涉及治疗。

主要观察指标

干燥综合征的诊断。

结果

该患者有口干症状、唾液腺活检结果异常、抗SSA和抗SSB抗体,以及与干燥综合征相关的组织相容性抗原HLA - B8和HLA - DR3。

结论

儿童复发性腮腺炎病例应考虑原发性干燥综合征。需要更多研究来评估儿童自身免疫性外分泌腺病的自然病程。

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Recurrent parotid swelling in children: clinical features useful for differential diagnosis of Sjögren's syndrome.儿童复发性腮腺肿胀:有助于干燥综合征鉴别诊断的临床特征
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引用本文的文献

1
Diseases of the salivary glands in infants and adolescents.婴幼儿唾液腺疾病。
Head Face Med. 2010 Feb 15;6:1. doi: 10.1186/1746-160X-6-1.
2
Primary Sjögren syndrome in the paediatric age: a multicentre survey.儿童期原发性干燥综合征:一项多中心调查。
Eur J Pediatr. 2003 Oct;162(10):661-5. doi: 10.1007/s00431-003-1277-9. Epub 2003 Jul 29.
3
Autosomal dominant juvenile recurrent parotitis.常染色体显性遗传性青少年复发性腮腺炎
J Med Genet. 1998 May;35(5):417-9. doi: 10.1136/jmg.35.5.417.