Provinciali L, Giovagnoli A R
Istituto delle Malattie del Sistema Nervoso, Università di Ancona, Italia.
Neuroepidemiology. 1990;9(5):255-62. doi: 10.1159/000110782.
Risk factors for amyotrophic lateral sclerosis (ALS) such as country of residence, hard labour, intense athletic activities, heavy metal and pet exposure, skeletal trauma, surgical procedures, malignancies, and recurrent infectious disease were investigated in 77 patients and 80 controls, matching the cases for selected parameters, hard work occurred more frequently in ALS patients than in controls; hard labour, skeletal trauma and exposure to heavy metals showed a high relative risk. Some differences were detected in the clinical evolution of ALS, as defined using the Norris scale. These findings support the role of some antecedent events in causing ALS but show that they have little influence on clinical features and disease evolution.
在77例肌萎缩侧索硬化症（ALS）患者和80例对照中，对ALS的危险因素进行了调查，这些危险因素包括居住国家、繁重体力劳动、高强度体育活动、接触重金属和宠物、骨骼创伤、外科手术、恶性肿瘤和反复感染性疾病。对照在选定参数上与病例相匹配，繁重体力劳动在ALS患者中比在对照中更频繁出现；繁重体力劳动、骨骼创伤和接触重金属显示出较高的相对风险。使用诺里斯量表定义的ALS临床进展中检测到一些差异。这些发现支持了某些先前事件在导致ALS中的作用，但表明它们对临床特征和疾病进展影响不大。
