大鼠苦杏仁苷毒性研究预测人类慢性氰化物中毒。
Amygdalin toxicity studies in rats predict chronic cyanide poisoning in humans.
作者信息
Newton G W, Schmidt E S, Lewis J P, Conn E, Lawrence R
出版信息
West J Med. 1981 Feb;134(2):97-103.
Abstract
Significant amounts of cyanide are released when amygdalin (Laetrile), a cyanogenic glycoside, is given orally or intravenously to rats. The amount of cyanide liberated following oral administration is dependent in part on the bacterial flora of the gut and can be suppressed by antibiotic pretreatment of the animals. Bacteria from human feces likewise hydrolyze amygdalin with release of cyanide. Humans taking amygdalin orally in the hope of preventing cancer are likely to be exposed to levels of cyanide in excess of that associated with the development of tropical ataxic neuropathy in people of underdeveloped countries where food containing cyanogenic glycosides is a staple part of the diet.
摘要
当向大鼠口服或静脉注射苦杏仁苷（维生素B17）（一种含氰糖苷）时，会释放出大量氰化物。口服后释放的氰化物量部分取决于肠道菌群，并且可以通过对动物进行抗生素预处理来抑制。来自人类粪便的细菌同样会水解苦杏仁苷并释放氰化物。口服苦杏仁苷以预防癌症的人可能会接触到超过与热带共济失调性神经病发生相关的氰化物水平，在不发达国家，含氰糖苷的食物是饮食的主要组成部分。
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Laetrile.苦杏仁苷
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