Matsumoto T, Iida M, Nakamura S, Hizawa K, Kuroki F, Fujishima M
Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Gastroenterol Jpn. 1993 Feb;28(1):10-7. doi: 10.1007/BF02774998.
The ulcerogenic effect of intracolonically administered indomethacin was evaluated in rats. Conventionally fed rats aged from 5 to 10 weeks were treated by 8, 16, 24, or 32 mg/kg of intracolonic indomethacin for two days, and any damage to the stomach, small intestine and the colon was investigated. Longitudinal ulcers and scattered small ulcers were found in the small intestine at all doses of indomethacin, and the length of the longitudinal ulcers increase dose-dependently, but this was unrelated to the body weight of the rats. The cecum was frequently affected by irregularly shaped ulcers, and the incidence increased as the dose of indomethacin increased. The colon, other than the cecum, was not involved macroscopically. In contrast, the stomach was affected by only large doses of indomethacin (24 or 32 mg/kg), and the size of gastric ulcers increased according to the body weight of the rats. These findings suggest that intracolonic indomethacin in relatively young rats causes ulcers predominantly in the small intestine and the cecum, which are the frequent site of involvement of human Crohn's disease, and that this animal model may be suitable for investigation of the pathophysiology of inflammatory bowel disease.
在大鼠中评估结肠内给予吲哚美辛的致溃疡作用。对5至10周龄的常规饲养大鼠，以8、16、24或32mg/kg的剂量结肠内给予吲哚美辛，持续两天，并研究对胃、小肠和结肠的任何损伤。在所有吲哚美辛剂量下，小肠均发现纵向溃疡和散在的小溃疡，纵向溃疡的长度呈剂量依赖性增加，但这与大鼠体重无关。盲肠经常受到形状不规则的溃疡影响，且随着吲哚美辛剂量的增加，发病率升高。除盲肠外，结肠在宏观上未受影响。相比之下，仅大剂量（24或32mg/kg）的吲哚美辛会影响胃，胃溃疡的大小随大鼠体重增加。这些发现表明，相对年轻大鼠结肠内给予吲哚美辛主要在小肠和盲肠引起溃疡，而小肠和盲肠是人类克罗恩病常见受累部位，且该动物模型可能适用于研究炎症性肠病的病理生理学。
