Matson D O, O'Ryan M L, Herrera I, Pickering L K, Estes M K
Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030.
J Infect Dis. 1993 Mar;167(3):577-83. doi: 10.1093/infdis/167.3.577.
The role of anti-rotavirus fecal IgA (RVflgA) in protecting children against natural rotavirus infections is unclear. Rotavirus outbreaks occurred in each of four day care centers attended by 129 children; 42% of the infections were asymptomatic. RVflgA titers were measured by EIA before infection and 4 weeks later in 50 children who excreted rotavirus (excretors) and in two samples 4 weeks apart from 50 children without detected virus excretion (nonexcretors). Forty-three (86%) excretors and 18 (36%) nonexcretors had a fourfold or greater RVflgA titer rise. Preexposure RVflgA titers were higher in not infected than symptomatic (P = .002), asymptomatic than symptomatic (P = .036), and not infected than asymptomatic children (P = .07). RVflgA titers after asymptomatic infections were slightly than after symptomatic infections (P = .087). In summary, higher RVflgA titers were associated with protection against infection and illness and increased fourfold or more in both asymptomatic and symptomatic children.
抗轮状病毒粪便IgA（RVflgA）在保护儿童免受自然轮状病毒感染方面的作用尚不清楚。129名儿童就读的四家日托中心均发生了轮状病毒暴发；42%的感染无症状。在50名排出轮状病毒的儿童（排病毒者）感染前及感染4周后，以及在50名未检测到病毒排出的儿童（未排病毒者）相隔4周的两个样本中，通过酶免疫测定法测量RVflgA滴度。43名（86%）排病毒者和18名（36%）未排病毒者的RVflgA滴度升高四倍或更高。未感染儿童的暴露前RVflgA滴度高于有症状儿童（P = 0.002），无症状儿童高于有症状儿童（P = 0.036），未感染儿童高于无症状儿童（P = 0.07）。无症状感染后的RVflgA滴度略高于有症状感染后（P = 0.087）。总之，较高的RVflgA滴度与预防感染和疾病相关，且在无症状和有症状儿童中均升高四倍或更多。
