系统性红斑狼疮中的IgA抗双链DNA抗体：发生率、发病率及其与疾病活动的临床和实验室指标的关联
IgA anti-dsDNA antibodies in systemic lupus erythematosus: occurrence, incidence and association with clinical and laboratory variables of disease activity.
作者信息
Miltenburg A M, Roos A, Slegtenhorst L, Daha M R, Breedveld F C
机构信息
Department of Rheumatology, University Hospital Leiden, The Netherlands.
出版信息
J Rheumatol. 1993 Jan;20(1):53-8.
The relationship between IgA anti-dsDNA antibodies and systemic lupus erythematosus (SLE) disease activity was investigated. IgA anti-dsDNA antibodies were measured using ELISA techniques. Elevated serum levels of IgA anti-dsDNA antibodies were detected in 51% of the patients with SLE (n = 57) and 8% of the diseased controls (n = 214). The presence of IgA anti-dsDNA antibodies was associated with kidney and joint abnormalities, with hypocomplementemia and with circulating immune complexes. We conclude that increased levels of IgA anti-dsDNA antibodies are associated with disease activity in patients with SLE.
研究了IgA抗双链DNA抗体与系统性红斑狼疮（SLE）疾病活动之间的关系。采用酶联免疫吸附测定（ELISA）技术检测IgA抗双链DNA抗体。在51%的SLE患者（n = 57）和8%的患病对照者（n = 214）中检测到血清IgA抗双链DNA抗体水平升高。IgA抗双链DNA抗体的存在与肾脏和关节异常、补体减少以及循环免疫复合物有关。我们得出结论，SLE患者中IgA抗双链DNA抗体水平升高与疾病活动相关。
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