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Oncogenic conversion of Ets affects redox regulation in-vivo and in-vitro.

作者信息

Wasylyk C, Wasylyk B

机构信息

CNRS-LEGME/INSERM-U. 184, Institut de Chimie Biologique, Faculté de Médecine, Strasbourg, France.

出版信息

Nucleic Acids Res. 1993 Feb 11;21(3):523-9. doi: 10.1093/nar/21.3.523.

DOI:10.1093/nar/21.3.523
PMID:8441665
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC309148/
Abstract

The avian acute leukemia virus E26 encodes a fusion protein between viral Gag and the cellular transcription factors cMyb and cEts1(p68). vEts on its own transforms more mature erythroid cells. We have compared the properties of vEts and cEts1(p68). vEts interacts preferentially with an antibody that recognizes the active conformation of the DNA-binding domain. The DNA-binding activity of vEts is particularly sensitive to incubation conditions for band-shift assays, phosphorylation and modification by sulphydryl-specific reagents. Increased sensitivity is due to loss of a protective function of cEts1 C-terminal sequences. cEts2 has a related C-terminal sequence with a similar role. These results suggest that the vEts DNA-binding domain is more accessible to protein-protein interactions and to regulatory mechanisms. Indeed, vEts DNA binding is preferentially inactivated by oxidizing conditions in-vivo. We suggest that the 'open' conformation of the vEts DNA-binding domain favours interactions with other proteins or DNA and facilitates transformation.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2228/309148/ff538b86231d/nar00052-0170-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2228/309148/a94bbcc7beb3/nar00052-0166-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2228/309148/400762b2548e/nar00052-0167-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2228/309148/c771a079fef1/nar00052-0167-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2228/309148/b1f5645180a2/nar00052-0168-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2228/309148/4a9e9ff1877c/nar00052-0168-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2228/309148/6328a967500e/nar00052-0168-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2228/309148/adaed630c0d6/nar00052-0169-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2228/309148/d9b39853e2c4/nar00052-0169-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2228/309148/c7201fdaa218/nar00052-0169-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2228/309148/ff538b86231d/nar00052-0170-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2228/309148/a94bbcc7beb3/nar00052-0166-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2228/309148/400762b2548e/nar00052-0167-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2228/309148/c771a079fef1/nar00052-0167-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2228/309148/b1f5645180a2/nar00052-0168-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2228/309148/4a9e9ff1877c/nar00052-0168-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2228/309148/6328a967500e/nar00052-0168-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2228/309148/adaed630c0d6/nar00052-0169-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2228/309148/d9b39853e2c4/nar00052-0169-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2228/309148/c7201fdaa218/nar00052-0169-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2228/309148/ff538b86231d/nar00052-0170-a.jpg

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Nucleic Acids Res. 1993 Feb 11;21(3):523-9. doi: 10.1093/nar/21.3.523.
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本文引用的文献

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A putative second cell-derived oncogene of the avian leukaemia retrovirus E26.禽白血病逆转录病毒E26一种假定的第二种细胞衍生癌基因。
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DNA and redox state induced conformational changes in the DNA-binding domain of the Myb oncoprotein.DNA与氧化还原状态诱导Myb癌蛋白DNA结合结构域的构象变化。
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Nucleic Acids Res. 1994 Sep 25;22(19):3871-9. doi: 10.1093/nar/22.19.3871.
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Redox regulation of fos and jun DNA-binding activity in vitro.
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Nature. 1990 Jul 12;346(6280):191-3. doi: 10.1038/346191a0.
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Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.活性氧中间体作为在NF-κB转录因子和HIV-1激活中明显广泛使用的信使。
EMBO J. 1991 Aug;10(8):2247-58. doi: 10.1002/j.1460-2075.1991.tb07761.x.
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Oncogenic conversion by regulatory changes in transcription factors.
Cell. 1991 Jan 25;64(2):303-12. doi: 10.1016/0092-8674(91)90640-k.
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Kappa B-specific DNA binding proteins are differentially inhibited by enhancer mutations and biological oxidation.κB特异性DNA结合蛋白受到增强子突变和生物氧化的不同程度抑制。
New Biol. 1991 Oct;3(10):987-96.
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erg, an ets-related gene, codes for sequence-specific transcriptional activators.erg是一种与ets相关的基因，编码序列特异性转录激活因子。
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