Ansari R A, Tripathi S C, Patnaik G K, Dhawan B N
Indian Council of Medical Research Centre for Advanced Pharmacological Research on Traditional Remedies, Central Drug Research Institute, Lucknow.
J Ethnopharmacol. 1991 Aug;34(1):61-8. doi: 10.1016/0378-8741(91)90189-k.
The hepatoprotective activity of picroliv, the irridoid glycoside mixture from Picrorhiza kurrooa, was determined in adult male albino rats. Pretreatment with picroliv prevented the hepatotoxic effects of paracetamol and galactosamine as evidenced by various biochemical and histopathological observations. Maximum hepatoprotective effect was observed with daily oral doses of 6 and 12 mg/kg for 7 or 8 days. The antihepatotoxic action of picroliv seems likely due to an alteration in the biotransformation of the toxic substances resulting in decreased formation of reactive metabolites.
在成年雄性白化病大鼠中测定了胡黄连苷（Picroliv）（一种从胡黄连中提取的环烯醚萜苷混合物）的肝脏保护活性。各种生化和组织病理学观察结果表明，用胡黄连苷预处理可预防对乙酰氨基酚和半乳糖胺的肝毒性作用。每日口服6毫克/千克和12毫克/千克，持续7天或8天，观察到最大肝脏保护作用。胡黄连苷的抗肝毒性作用可能是由于有毒物质生物转化的改变，导致活性代谢产物的形成减少。
