Lai H, Carino M A, Horita A, Guy A W
Department of Pharmacology, University of Washington, Seattle 98195.
Bioelectromagnetics. 1993;14(1):5-15. doi: 10.1002/bem.2250140104.
We studied the effects of an acute (45 min) exposure to a 60 Hz magnetic field on sodium-dependent, high-affinity choline uptake in the brain of the rat. Decreases in uptake were observed in the frontal cortex and hippocampus after the animals were exposed to a magnetic field at flux densities > or = 0.75 mT. These effects of the magnetic field were blocked by pretreating the animals with the narcotic antagonist naltrexone, but not by the peripheral opioid antagonist, naloxone methiodide. These data indicate that the magnetic-field-induced decreases in high-affinity choline uptake in the rat brain were mediated by endogenous opioids in the central nervous systems.
我们研究了急性（45分钟）暴露于60赫兹磁场对大鼠脑内钠依赖性、高亲和力胆碱摄取的影响。当动物暴露于通量密度≥0.75毫特斯拉的磁场后，额叶皮质和海马体中的摄取量出现下降。磁场的这些效应可通过用麻醉拮抗剂纳曲酮对动物进行预处理来阻断，但不能被外周阿片拮抗剂甲硫氨酸纳洛酮阻断。这些数据表明，大鼠脑内磁场诱导的高亲和力胆碱摄取减少是由中枢神经系统中的内源性阿片类物质介导的。
