Ikeda M, Kawabata M, Kuga M, Nakazato H
Department of Otolaryngology, Nihon University School of Medicine, Tokyo, Japan.
Eur Arch Otorhinolaryngol. 1993;249(8):488-91. doi: 10.1007/BF00168862.
Ninety-eight patients with facial paralysis were studied by an indirect enzyme-linked immunosorbent assay (ELISA) employing two types of Borrelia burgdorferi antigen, namely sonic extract and flagellum protein of B. burgdorferi. IgG or IgM antibodies were detected by sonic extract ELISA in 22 (32.4%) of 68 patients with Bell's palsy, and in 2 (10.0%) of 20 patients with varicella-zoster virus infection. This difference was statistically significant (P < 0.05). A positive reaction was more frequent with the sonic extract antigen, while the positive rates were significantly increased in Bell's palsy patients with hyperglobulinemia (P < 0.05). IgM antibodies were also significantly more frequently observed in patients who developed Bell's palsy between October and March (P < 0.05). Since none of the patients had a history suggestive of Lyme disease, some kind of non-specific reaction and certain undefined factors linked to a positive reaction against B. burgdorferi could be involved in Bell's palsy.
采用间接酶联免疫吸附测定（ELISA），使用两种伯氏疏螺旋体抗原，即伯氏疏螺旋体的超声提取物和鞭毛蛋白，对98例面瘫患者进行了研究。在68例贝尔麻痹患者中，有22例（32.4%）通过超声提取物ELISA检测到IgG或IgM抗体，在20例水痘-带状疱疹病毒感染患者中有2例（10.0%）检测到。这种差异具有统计学意义（P<0.05）。超声提取物抗原的阳性反应更为常见，而在高球蛋白血症的贝尔麻痹患者中阳性率显著升高（P<0.05）。在10月至次年3月期间发生贝尔麻痹的患者中，IgM抗体也明显更频繁地被观察到（P<0.05）。由于所有患者均无提示莱姆病的病史，贝尔麻痹可能涉及某种非特异性反应以及与针对伯氏疏螺旋体的阳性反应相关的某些未明确因素。
