Roubenoff R, Rall L C
US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111.
Nutr Rev. 1993 Jan;51(1):1-11. doi: 10.1111/j.1753-4887.1993.tb03045.x.
A decline in lean body mass and an accompanying increase in fat mass are known to occur during aging. The consequences of these changes in body composition may include decreased strength and physical activity, altered energy metabolism, and impaired resistance to infection. The mechanisms behind these age-related events remain unknown, but they may include changes in some of the hormonal and cytokine mediators that seem to regulate body composition. The common inflammatory condition rheumatoid arthritis could provide a useful model of these phenomena dissociated from chronological aging. This article reviews changes in neuroendocrine and immune modulators of metabolism and their consequences during aging and chronic inflammation.
众所周知，在衰老过程中会出现瘦体重下降以及随之而来的脂肪量增加。身体成分这些变化的后果可能包括力量和体力活动下降、能量代谢改变以及抗感染能力受损。这些与年龄相关事件背后的机制尚不清楚，但可能包括一些似乎调节身体成分的激素和细胞因子介质的变化。常见的炎症性疾病类风湿性关节炎可能为这些与自然衰老无关的现象提供一个有用的模型。本文综述了衰老和慢性炎症过程中神经内分泌和免疫代谢调节因子的变化及其后果。
